At the beginning of the 20th century, in the heart of the Amazon forest, a rail line is carved through the jungle. The ambitious project costs the lives of many workers. Taking care of the health of these laborers is the young American doctor Richard Finnegan. He is enchanted by the jungle’s beauty and appalled by the labor conditions. Amidst the horror and political wrangling that encumber the operation, Dr.Finnegan falls in love with Consuelo, who was rescued in the jungle on the verge of death. Mad Maria is the dramatic story of the men who faced the horror of the forest and the passion of a couple in the midst of the chaos.